# A Rare Case of Dual Metachronous Primary Malignancies, Chronic Myeloid Leukemia, and Tongue Carcinoma in a Patient With Long-Standing Systemic Lupus Erythematosus: A Case Report and Review of Literature

## TL;DR

A rare case of a patient with long-term lupus who developed two cancers, chronic myeloid leukemia and tongue cancer, is reported and reviewed.

## Contribution

This case highlights the rare occurrence of dual metachronous malignancies in a patient with SLE.

## Key findings

- CML is rarely reported in patients with SLE.
- Mucosal SCC of the head and neck is uncommon in CML survivors.
- Multidisciplinary management is crucial for such complex cases.

## Abstract

Patients with long-standing autoimmune diseases like systemic lupus erythematosus (SLE) are at a higher risk of developing hematological malignancies. However, chronic myeloid leukemia (CML) has rarely been reported in patients with SLE. Advancements in medical diagnostics and treatment have led to the life expectancy of SLE and CML patients moving closer to that of the general population, and it is not uncommon to encounter more than one malignancy in a cancer survivor. Although squamous cell carcinoma (SCC) of the skin has been reported in CML patients, mucosal SCC of the head and neck has rarely only been reported in CML survivors. The objective of this case report is to share our experience in treating a patient with dual metachronous primary malignancies, CML, and tongue carcinoma, along with long-standing SLE, managed by a multidisciplinary team.