# Complex Cardiovascular Morbidities in Prader-Willi Syndrome: A Multidisciplinary Approach

**Authors:** Raul Alba, Soroush Omidvarnia, Jared J Bies, Tim Carlson, Qusay Alfaori, Thwe Htay

PMC · DOI: 10.7759/cureus.56591 · Cureus · 2024-03-20

## TL;DR

This paper highlights the complex cardiovascular issues in Prader-Willi Syndrome and the importance of a multidisciplinary treatment approach.

## Contribution

The paper presents a case study emphasizing the need for interdisciplinary care in managing cardiovascular complications in PWS.

## Key findings

- PWS patients can have multiple coexisting cardiovascular and metabolic conditions.
- A collaborative approach involving various specialists is essential for effective management.
- Current treatments focus on symptom management, but genetic research may offer future improvements.

## Abstract

This case emphasizes the complexity of Prader-Willi syndrome (PWS), the need for a collaborative approach from specialists, and a closer look at the various cardiovascular complexities associated with this syndrome. While current treatments focus on managing symptoms, ongoing genetic research offers hope for more favorable outcomes. Further studies are crucial to gauge the effectiveness of these treatments for PWS patients. We detail a patient with a complex medical history of PWS, further complicated by congenital heart disease with Eisenmenger’s syndrome, diabetes mellitus, pulmonary hypertension, venous insufficiency, hypothyroidism, and hyperlipidemia. Reported in this study is a compilation of clinical data as well as suggestions from several medical specialists in applying a multifaceted approach to treatment, significantly emphasizing the need for interdisciplinary care and management of patients experiencing a combination of various medical issues with an emphasis on cardiovascular complications.

## Linked entities

- **Diseases:** Prader-Willi syndrome (MONDO:0008300), congenital heart disease (MONDO:0005453), Eisenmenger’s syndrome (MONDO:0019944), diabetes mellitus (MONDO:0005015), pulmonary hypertension (MONDO:0005149), venous insufficiency (MONDO:0000945), hypothyroidism (MONDO:0005420), hyperlipidemia (MONDO:0021187)

## Full-text entities

- **Diseases:** venous insufficiency (MESH:D014689), diabetes mellitus (MESH:D003920), cardiovascular complications (MESH:D002318), pulmonary hypertension (MESH:D006976), Eisenmenger's syndrome (MESH:D004541), hyperlipidemia (MESH:D006949), PWS (MESH:D011218), congenital heart disease (MESH:D006330), hypothyroidism (MESH:D007037)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11031429/full.md

## References

18 references — full list in the complete paper: https://tomesphere.com/paper/PMC11031429/full.md

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Source: https://tomesphere.com/paper/PMC11031429