Analysis of risk factors and changes in myocardial biomarker levels in 122 cases of early neonatal anemia

TL;DR

This study identifies risk factors for early neonatal anemia and finds that anemic newborns have higher levels of heart-related biomarkers.

Contribution

The study identifies specific risk factors and their impact on myocardial biomarker levels in early neonatal anemia.

Findings

Preterm birth, multiple pregnancy, and abnormal placenta are independent risk factors for early neonatal anemia.

Anemic newborns had significantly higher levels of cTnT, CK-MB, and LDH compared to nonanemic newborns.

Early neonatal anemia is associated with increased myocardial marker expression.

Abstract

Anemia in the first week after birth, which could affect growth, development, and organ function, should be an important warning sign to clinicians. The aim of this study was to assess the related risk factors of early neonatal anemia and to analyze the effect of anemia on the expression levels of myocardial markers in newborns.

Clinical data from 122 confirmed cases of anemic newborns and 108 nonanemic newborns were collected to analyze the independent risk factors for early anemia using logistic regression analyses. Blood samples were collected from both groups for the detection of myocardial markers, including the protein marker cardiac troponin T (cTnT), as well as enzyme markers creatine kinase isoenzyme MB (CK-MB) and lactate dehydrogenase (LDH).

Multivariate logistic regression analysis revealed that preterm birth (OR: 3.589 [1.119–11.506], p < 0.05), multiple pregnancy (OR: 4.117 [1.021–16.611], p < 0.05), and abnormal placenta (OR: 4.712 [1.077–20.625], p < 0.05) were independent risk factors for early neonatal anemia. The levels of myocardial markers, including cTnT (303.1 ± 244.7 vs. 44.2 ± 55.41 ng/L), CK-MB (6.803 ± 8.971 vs. 2.5326 ± 2.927 μkat/L), and LDH (32.42 ± 35.26 vs. 19.73 ± 17.13 μkat/L), were significantly higher in the anemic group than in the nonanemic group.

Multiple pregnancy, preterm birth, and abnormal placenta were identified as risk factors for early neonatal anemia. The occurrence of early neonatal anemia was associated with increased levels of myocardial markers.

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