# Factors Affecting Upper Limb Fracture Opioid Requirements

## TL;DR

This study identifies factors influencing opioid use in patients with upper limb fractures, helping clinicians better predict pain management needs.

## Contribution

The study provides a detailed analysis of fracture locations and comorbidities linked to higher opioid requirements over a one-year period.

## Key findings

- Fractures of the scapula, proximal humerus, and humeral shaft were associated with higher opioid strength and coverage.
- Patients with depression, pulmonary disease, and rheumatological conditions required more opioids in terms of strength and coverage.
- Radius shaft and distal radius fractures had significantly lower opioid requirements compared to other upper limb fractures.

## Abstract

Introduction

Understanding the different opioid pain relief requirements between patients with upper limb fractures can be useful in forming specific evidence-based guidelines and balancing patient-clinician prescribing discussions with opioid stewardship. We investigated the predictors for opioid requirements in upper limb fractures.

Methods

We retrospectively investigated all upper limb fractures from the shoulder to the wrist treated at a major trauma center from January 2015 to January 2022. The data collected consisted of fracture location, demographics, comorbidities, and management options. Post-injury opioid prescriptions in the first post-injury year were calculated every month up to six months and then grouped from the seventh to the 12th month and converted to morphine milligram equivalents (MMEs). We then calculated days requiring at least one medication (representing the “coverage”) and relative “strength” in each time period.

Results

Six thousand four hundred thirteen patients sustaining a combined 9125 fractures were included in the study, with an MME mean of 436. Fracture locations of the scapula, proximal humerus, humeral shaft, distal humerus, and proximal ulna all had significantly higher MME requirements (p<0.05) at the one-year level. The radius shaft and distal radius had significantly lower MME requirements (p<0.05).

The patients with depression, diabetes, drug abuse history, obesity, pulmonary circulatory disorder, and rheumatological conditions required higher strength of opioids at the one-year level (p<0.05). The patients with chronic kidney disease, depression, pulmonary circulation disorder, and rheumatological conditions required higher coverage of opioids at the one-year level (p<0.05).

Conclusion

Our study presents a high-resolution breakdown of the post-injury opioid requirements for patients with upper limb injuries. Fractures of the scapula, proximal humerus, and shaft of the humerus were associated with increases in both opioid strength and coverage. Depression, pulmonary disease, and rheumatological conditions were all associated with increased opioid strength and coverage. This provides a framework for which clinicians and patients can more accurately anticipate the course of the rehabilitation journey and risk stratify appropriately at the outset of injury.