# Case report: Highly response to low-dose brachytherapy in recurrent retroperitoneal leiomyosarcoma with FANCD2 frameshift mutation: a unique case study

## TL;DR

A man with a rare muscle tumor responded strongly to low-dose radiation therapy, possibly due to a specific genetic mutation.

## Contribution

This case study highlights a unique response to low-dose brachytherapy in a patient with a FANCD2 mutation in leiomyosarcoma.

## Key findings

- The patient showed a rapid and robust clinical response to low-dose iodine-125 brachytherapy.
- A FANCD2 frameshift mutation was identified in the tumor tissue through gene sequencing.

## Abstract

We report a case of recurrent retroperitoneal leiomyosarcoma in a male who achieved a rapid and robust but transient clinical response to low-dose iodine-125 brachytherapy. A FANCD2 frameshift mutation was detected by gene sequencing in the cancerous tissue.