A Rare Case Report of Dedifferentiated Endometrioid Carcinoma

TL;DR

This paper reports a rare case of dedifferentiated endometrioid carcinoma in a 64-year-old woman, highlighting the challenges in diagnosis and the need for tailored treatment.

Contribution

The novelty lies in presenting a rare and complex case of DEC with a focus on accurate diagnosis and multidisciplinary management.

Findings

The tumor was composed of both high-grade and low-grade components, often mislabeled as FIGO Grade 2 or 3 endometrioid carcinoma.

A multidisciplinary approach including surgery, chemotherapy, and radiation was used for management.

Early recognition and tailored strategies are essential for treating dedifferentiated endometrioid carcinoma.

Abstract

Dedifferentiated endometrioid carcinoma (DEC) is an exceptionally rare subtype of endometrial cancer characterized by a high-grade component juxtaposed with a low-grade endometrioid adenocarcinoma. This case report presents a unique instance of dedifferentiated endometrioid carcinoma in a 64-year-old female patient who presented with post-menopausal bleeding and abdominal pain. Diagnostic evaluation including imaging studies and histopathological examination revealed a mixed tumor comprising both high-grade and low-grade components. Management involved a multidisciplinary approach including surgical resection followed by adjuvant chemotherapy and radiation therapy. They are frequently mislabeled as endometrioid carcinomas of International Federation of Gynecology and Obstetrics (FIGO) Grade 2 or Grade 3. It is crucial to correctly differentiate these instances from traditional endometrioid carcinomas. This case underscores the importance of early recognition and comprehensive management strategies tailored to the unique characteristics of dedifferentiated endometrioid carcinoma. We report this case due to its rarity and complexity in diagnosis.

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