Factors associated with venous collaterals in patients with cerebral venous thrombosis

TL;DR

This study finds that younger age, superior sagittal sinus occlusion, and hormonal exposure are linked to venous collaterals in cerebral venous thrombosis patients.

Contribution

The study identifies hormonal exposure and superior sagittal sinus occlusion as independent factors associated with venous collaterals in cerebral venous thrombosis.

Findings

Venous collaterals were present in 25.3% of cerebral venous thrombosis patients.

Occlusion in the superior sagittal sinus was independently associated with venous collaterals.

Hormonal exposure significantly increased the likelihood of venous collaterals.

Abstract

To identify the factors associated with venous collaterals in Thai patients with cerebral venous thrombosis.

This retrospective 20-year cohort study enrolled patients diagnosed with cerebral venous thrombosis between January 2002 and December 2022. Data was collected from the electronic medical record, and venous collaterals were independently reviewed by two neuroradiologists using the Qureshi classification. Patients with and without venous collaterals were compared. Significant factors (P<0.05) in the univariate analysis were recruited into the multivariate logistic regression analysis to determine independently associated factors.

Among 79 patients with cerebral venous thrombosis, the prevalence of venous collaterals at the initial neuroimaging was 25.3%. In the univariate analysis, patients with cerebral venous thrombosis and venous collaterals were significantly younger (37.0±13.9 years vs. 44.9±17.4 years, P = 0.048), more often had occlusion in the superior sagittal sinus (80.0% vs. 54.2%, P = 0.041), and were associated with hormonal exposure (35.0% vs. 6.8%, P = 0.002). Multivariate logistic regression analysis revealed occlusion in the superior sagittal sinus (adjusted odds ratio [aOR] 3.581; 95% confidence interval [95% CI] 1.941–13.626; P = 0.044) and hormonal exposure (aOR 7.276, 95% CI 1.606–32.966, P = 0.010) as independent factors associated with venous collaterals in cerebral venous thrombosis.

In this cohort, the prevalence of venous collaterals was 25.3%. Occlusion in the superior sagittal sinus and hormonal exposure were independently associated with venous collaterals in patients with cerebral venous thrombosis.

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