# Reply to Johansson ‘Treatment with BRICHOS domain helps to clarify issues with Alzheimer mouse models’

## TL;DR

This paper responds to a critique about using BRICHOS domains to study Alzheimer's disease in mice.

## Contribution

The paper defends the use of BRICHOS domains in clarifying Alzheimer's pathology in mouse models.

## Key findings

- BRICHOS domains are useful for studying amyloid pathology in Alzheimer's models.
- The authors clarify misunderstandings about their experimental approach and results.

## Abstract

This correspondence is a reply to correspondence from Dr. Jan Johansson on the utility of BRICHOS domains in understanding pathology in Alzheimer’s disease mouse models.