# Multisystem Inflammatory Syndrome in Adults-Related Unstable Angina With Coronary Aneurysm in a Young Female: A Case Report

**Authors:** Hiroki Aihara

PMC · DOI: 10.7759/cureus.56162 · Cureus · 2024-03-14

## TL;DR

A young woman developed unstable angina and coronary aneurysms six months after a COVID-19 infection, treated surgically and with approaches similar to Kawasaki disease.

## Contribution

This case report highlights the potential long-term cardiovascular complications of MIS-A and the need for further research on its pathology and prognosis.

## Key findings

- A 27-year-old female developed unstable angina and coronary aneurysms six months after a confirmed COVID-19 infection.
- Treatment for unstable angina included surgery, which improved her chest pain.
- The case suggests a possible link between MIS-A and coronary artery lesions similar to those seen in Kawasaki disease.

## Abstract

Multisystem inflammatory syndrome in adults (MIS-A) is a systemic inflammatory disease associated with COVID-19 and follows coronary artery aneurysms similar to Kawasaki disease. In many cases, it is improved by treatments such as high-dose steroids or intravenous immunoglobulin (IVIg). However, the role of untreated coronary artery aneurysms leading to future stenosis remains unknown. Untreated MIS-A may potentially lead to the formation of coronary aneurysms. In cases of COVID-19 where young adults present with angina-like symptoms, an evaluation for angina is considered. Herein, we report a case of a 27-year-old female who developed unstable angina with coronary artery aneurysms six months after COVID-19 infection. She required surgery for unstable angina, which resulted in an improvement in chest pain. Coronary artery lesions are considered to be related to MIS-A, and treatment was conducted in accordance with that for Kawasaki disease. Currently, the pathological differences and prognosis between MIS-A and Kawasaki disease remain unclear, but the elucidation of the conditions is warranted in the future.

## Linked entities

- **Diseases:** Kawasaki disease (MONDO:0012727), unstable angina (MONDO:0006805), COVID-19 (MONDO:0100096)

## Full-text entities

- **Diseases:** Coronary artery lesions (MESH:D003324), Kawasaki disease (MESH:D009080), Coronary Aneurysm (MESH:D003323), stenosis (MESH:D003251), MIS-A (MESH:C000718087), Unstable Angina (MESH:D000789), COVID-19 (MESH:D000086382), systemic inflammatory disease (MESH:D018746), chest pain (MESH:D002637), angina (MESH:D000787)
- **Chemicals:** steroids (MESH:D013256)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11015871/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC11015871/full.md

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Source: https://tomesphere.com/paper/PMC11015871