# A putative role for lactate in the crosstalk between chemokines and glycolysis in solid cancer

## TL;DR

This paper explores how lactate, chemokines, and glycolysis interact to promote cancer progression.

## Contribution

The paper proposes a new pro-tumoral loop involving lactate, chemokines, and glycolysis.

## Key findings

- High glucose levels may drive a lactate-chemokine-glycolysis loop in cancer.
- Lactate acts as an immunomodulator influencing tumor cell behavior.
- Chemokines and glycolysis are interconnected in carcinogenesis.

## Abstract

Chemokines are very important for carcinogenesis and the development of a malignant phenotype. Lactate is a small molecule produced during glycolysis; recently it has emerged as an immunomodulator that could impact tumor cell behavior. In this paper we explore the interplay between chemokines, glycolysis, and lactate in cancer progression, and propose the existence of a pro-tumoral lactate-chemokine-glycolysis loop driven by high glucose levels.