# Transient activation of retinopathy of prematurity secondary to erythrocyte suspension transfusion

## TL;DR

This case report shows that giving red blood cell transfusions to premature infants can temporarily worsen a serious eye condition, but it often resolves on its own.

## Contribution

The novelty lies in demonstrating that ROP progression after erythrocyte suspension transfusion can be transient and self-resolving in some cases.

## Key findings

- Two premature infants developed type 1 ROP after erythrocyte suspension transfusion.
- Clinical findings resolved within a few days without intervention.
- Observation for 24-48 hours is suggested before deciding on treatment.

## Abstract

Retinopathy of prematurity (ROP) is a serious retinal vascular disorder that needs prompt diagnosis, and treatment to prevent undesired visual outcomes. Due to its shorter period of disease progression, it is important to be hasty in treating ROP. Erythrocyte suspension (ES) aggravates the progression of ROP. However, this progression may be transient as in the present case reports. This case report aimed to present two cases that developed type 1 ROP after erythrocyte suspension transfusion. Clinical findings of the patients were resolved within a few days without any intervention. Premature infants receiving ES treatment can be observed for 24-48 hours, and the treatment can be planned after determining the persistence of the plus sign.

Abbreviations: ES = Erythrocyte suspension, ROP = Retinopathy of prematurity, NICU = neonatal intensive care unit