# First Case Report of Deferiprone-Induced Anaphylactic Reaction

**Authors:** Naharuthai Bumrungratanayos, Songphol Tungjitviboonkun

PMC · DOI: 10.7759/cureus.57847 · Cureus · 2024-04-08

## TL;DR

This paper reports the first case of a severe allergic reaction to deferiprone, a medication used to treat high iron levels.

## Contribution

The paper presents the first documented case of anaphylactic shock caused by deferiprone.

## Key findings

- A 56-year-old man with known drug allergies had an anaphylactic reaction to deferiprone.
- Symptoms were resolved with epinephrine, chlorpheniramine, and hydrocortisone.
- This case highlights the potential for severe allergic reactions to deferiprone.

## Abstract

A 56-year-old Thai male, known for allergies to penicillin, sulfa, and lincosamide, presented with hyperferritinemia. Upon initiating deferiprone therapy, the patient experienced recurrent episodes of dyspnea, culminating in anaphylactic shock. Treatment included subcutaneous epinephrine, intravenous chlorpheniramine, and hydrocortisone, which led to symptom resolution. This case constitutes the first case report of deferiprone-associated anaphylactic reactions.

## Linked entities

- **Chemicals:** deferiprone (PubChem CID 2972), epinephrine (PubChem CID 838), chlorpheniramine (PubChem CID 2725), hydrocortisone (PubChem CID 5754)
- **Diseases:** hyperferritinemia (MONDO:0958237), anaphylactic shock (MONDO:0100053)

## Full-text entities

- **Diseases:** Anaphylactic Reaction (MESH:D000707), hyperferritinemia (MESH:D000085583), dyspnea (MESH:D004417), allergies (MESH:D004342)
- **Chemicals:** penicillin (MESH:D010406), lincosamide (MESH:D055231), epinephrine (MESH:D004837), Deferiprone (MESH:D000077543), chlorpheniramine (MESH:D002744), hydrocortisone (MESH:D006854), sulfa (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC11002473/full.md

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Source: https://tomesphere.com/paper/PMC11002473