# Comparison of clinical outcomes of venous thromboembolic disease between outpatient and inpatient management

## TL;DR

The study found that patients hospitalized for venous thromboembolic disease had higher 90-day mortality compared to those managed as outpatients, with no significant differences in bleeding or recurrence.

## Contribution

This study provides new insights into the clinical outcomes of inpatient versus outpatient management of VTE in an elderly, predominantly female population.

## Key findings

- Hospitalized VTE patients had a 90-day mortality rate of 42.9% compared to 18.9% for outpatients.
- Outpatient management showed no significant difference in recurrence or major bleeding compared to inpatient care.

## Abstract

To compare the occurrence of death, bleeding, and recurrence according to inpatient or outpatient management of venous thromboembolic disease (VTE).

. Retrospective cohort that included a consecutive sampling of VTE consultations between 2016 and 2019 diagnosed in the Emergency Center of a private hospital in Argentina.

There were 1202 cases, 908 with isolated deep vein thrombosis (DVT), 205 with isolated pulmonary embolism (PE), and 89 cases of combined DVT - PE. 66% were women, with a median age of 77 years; 72% of cases were managed on an outpatient basis (n= 862). Comorbidities associated with hospitalization were obesity (p=0.03), chronic obstructive pulmonary disease (COPD) (p=0.01), heart failure (CHF) (p=0.01), chronic renal failure (CKD) (p=0.01), and cancer (p=0.01). At 90 days, the cumulative incidence of bleeding was 2.6% in inpatient compared to 2.9% in outpatient management (p=0.81); recurrence was 0% versus 0.9% (p=0.07), and mortality was 42.9% versus 18.9%, respectively (p=0.01). The HR for 90-day mortality in hospitalized patients adjusted for confounders (sex, age, type of VTE, obesity, CKD, CHF, COPD, and cancer) was 1.99 (95% CI 1.49-2.64; p=0.01).

In this elderly, and predominantly female Argentine population, the 90-day mortality in patients hospitalized for VTE was higher than mortality in patients with outpatient management, without differences in recurrence or major bleeding.