# Accelerated atherosclerosis in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: case report

## TL;DR

A 60-year-old patient with multiple health issues experienced rapid heart disease progression linked to an autoimmune condition called microscopic polyangiitis.

## Contribution

This case report highlights accelerated atherosclerosis as a complication of microscopic polyangiitis and emphasizes the importance of early diagnosis.

## Key findings

- The patient had two acute coronary events within six months, indicating rapid coronary involvement.
- Positive anti-MPO antibodies and inflammatory markers led to a diagnosis of microscopic polyangiitis.

## Abstract

Accelerated atherosclerosis has been identified as a complication of multiple autoimmune diseases, among which Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis stands out. We describe the case of a 60-year-old patient with a history of hypertension, diabetes mellitus, and chronic kidney disease of unknown etiology, who presented two acute coronary syndromes with only a six-month difference. Rapid progression of coronary involvement was evidenced, along with increased markers of inflammatory response, usual interstitial pneumonia on tomography, and positive anti-myeloperoxidase antibodies (anti-MPO), leading to the diagnosis of microscopic polyangiitis (MPA). In these cases, timely diagnostic suspicion is crucial, as early treatment significantly impacts the course and prognosis of the disease.