# Leptomeningeal Dissemination Complicated With Acute Tetraplegia From a Supratentorial Multicentric Isocitrate Dehydrogenase (IDH)-Wildtype Glioblastoma: A Case Report

## TL;DR

This case report describes a rare complication of glioblastoma in a young woman, where the cancer spread to the meninges and caused severe neurological symptoms.

## Contribution

The novelty lies in documenting a rare case of LMD in a young patient with IDH-wildtype GBM and its clinical progression.

## Key findings

- The patient developed hydrocephalus and extensive leptomeningeal dissemination three months after initial surgery.
- The case highlights the diagnostic challenges of LMD due to its similarity with infectious meningitis.
- The tumor was confirmed to be IDH-wildtype, a less common subtype in young patients.

## Abstract

Glioblastoma (GBM) is a major concern for neurosurgeons and oncologists, being a malignant tumor with a high recurrence rate and reduced survival. Leptomeningeal dissemination (LMD) of GBM is rare and difficult to diagnose due to the low rate of cellular detection in the cerebrospinal fluid and clinical and imaging similarities with fungal and tuberculous meningitis. We report the case of a 25-year-old female patient suffering from multicentric GBM who developed hydrocephalus and extensive LMD three months after surgery for a left frontal parafalcine cerebral GBM isocitrate dehydrogenase (IDH)-wildtype.