# Pulmonary and Urologic Sarcoidosis as a Cause of Intermittent Fever of Unknown Origin

## TL;DR

This paper discusses a rare case where sarcoidosis in the lungs and urinary tract caused a persistent fever with no clear diagnosis.

## Contribution

The paper highlights the unusual presentation of sarcoidosis as a cause of fever of unknown origin.

## Key findings

- Sarcoidosis can manifest as fever of unknown origin despite affecting multiple organs.
- A 61-year-old man with urologic sarcoidosis developed intermittent fever after treatment for an infection.
- Diagnosis of sarcoidosis relies on clinicopathologic findings and ruling out other granulomatous diseases.

## Abstract

Diagnosing fever of unknown origin (FUO) presents a substantial challenge due to its potential association with various diseases affecting different organs. In 1961, Petersdorf and Beeson initially defined FUO as a condition characterized by a temperature exceeding 38.3 °C on at least three occasions over a minimum three-week period. Despite a week of inpatient investigation, a definitive diagnosis remains unclear.

Sarcoidosis, a granulomatous disease impacting multiple systems, is among the causes of FUO. While the lungs are commonly affected, any organ can be involved, leading to diverse manifestations and clinical courses. Diagnosis relies on clinicopathologic findings and the exclusion of alternative causes of granulomatous disease. The hallmark of sarcoidosis is the development of granulomas in affected organs.

Here, we present the case of a 61-year-old man with a history of recurrent spontaneous periurethral abscesses who underwent multiple urological interventions. He developed FUO during hospitalization following treatment for the infectious condition.