# Fosfomycin-Induced Liver Injury: A Case Report

## TL;DR

A 73-year-old woman developed liver injury after taking fosfomycin, highlighting its potential to cause drug-induced liver damage.

## Contribution

This report adds a new clinical case of fosfomycin-induced liver injury to the medical literature.

## Key findings

- A 73-year-old female developed acute liver injury six days after fosfomycin use.
- The patient improved significantly within a week and fully recovered within a month.
- The case was confirmed as drug-induced liver injury after excluding other causes.

## Abstract

Fosfomycin is an antibiotic frequently used to treat uncomplicated urinary tract infections. It is normally well-tolerated, but there are some reports of clinically relevant liver injury. We present the case of a 73-year-old female who presented with paucisymptomatic hepatocellular acute liver injury six days after taking fosfomycin. After ruling out viral, ischemic, and autoimmune hepatitis, as well as Wilson disease and biliary disorders, she was diagnosed with drug-induced liver injury (DILI) related to fosfomycin. The patient showed major improvement during the first week and the resolution of liver injury one month after onset. This case report aims to underscore the potential hepatotoxicity of fosfomycin.