# VeloPro: A pipeline integrating Ribo‐seq and AlphaFold deciphers association patterns between translation velocity and protein structure features

## TL;DR

VeloPro combines Ribo-seq and AlphaFold to study how translation speed relates to protein structure across various organisms.

## Contribution

The novel integration of Ribo-seq data with AlphaFold2 predictions to explore translation velocity and protein structure associations.

## Key findings

- Translation velocity associations with protein structure features vary across different organisms.
- These associations partially reflect the taxonomical relationships among organisms.

## Abstract

VeloPro integrates Ribo‐seq data and AlphaFold2‐predicted 3D protein structure information for characterization of the association patterns between translation velocity and many protein structure features in prokaryotic and eukaryotic organisms across different taxonomical clades such as bacteria, fungi, protozoa, nematode, plants, insect, and mammals. We illustrated that association patterns between translation velocity and protein structure features differ across organisms, partially reflecting their taxonomical relationship.