# Laryngeal Ganglioneuromatosis in a Child With Multiple Endocrine Neoplasia Type 2B (MEN2B): Case Report and Review of Literature

## TL;DR

This paper reports a rare case of laryngeal ganglioneuromatosis in a child with MEN2B and reviews related literature.

## Contribution

The paper presents the third documented case of laryngeal neuroma in a pediatric MEN2B patient.

## Key findings

- Laryngeal neuromas are extremely rare in MEN2B patients.
- The case involved a laryngeal neuroma localized to the left true vocal cord.
- Early diagnosis and management of MEN2B are critical due to the risk of medullary thyroid carcinoma.

## Abstract

Multiple Endocrine Neoplasia type 2B (MEN2B) is an autosomal dominant cancer syndrome caused by a mutation in rearranged during transfection (RET) proto-oncogene and includes medullary thyroid carcinoma, pheochromocytoma, gastrointestinal neuromas, and mucosal ganglioneuromas. Medullary thyroid carcinoma is the major cause of mortality in MEN2B syndrome. Medullary thyroid carcinoma can often appear during the first years of life. While mucosal neuromas in MEN2B are common, laryngeal neuromas are extremely rare. We present a third case of a pediatric patient with a laryngeal neuroma localized to the left true vocal cord and conduct a literature review of vocal cord neuromas in MEN2B patients.