# Adverse fetal birth outcomes and its associated factors among mothers with premature rupture of membrane in Amhara region, Ethiopia

## TL;DR

This study in Ethiopia finds that 33% of mothers with premature membrane rupture had adverse birth outcomes, linked to factors like anemia and infections.

## Contribution

The study identifies key risk factors for adverse birth outcomes in mothers with PROM in the Amhara region, a previously under-researched area.

## Key findings

- 33.1% of mothers with PROM experienced adverse birth outcomes.
- Rural residence and a history of urinary tract infection were strongly associated with adverse outcomes.
- Anemia and short interpregnancy intervals also significantly increased the risk.

## Abstract

Adverse birth outcomes are the leading cause of neonatal mortality worldwide. Ethiopia is one of the countries struggling to reduce neonatal mortality through different strategies, but neonatal mortality remains high for many reasons. Despite adverse birth outcomes being a public health problem in Ethiopia, the contribution of Premature rupture of the membrane to the adverse fetal birth outcome is neglected and not well explained in our country. This study aims to assess fetal birth outcomes and associated factors among mothers with all types of PROM at Specialized Hospitals in Amhara Region, Ethiopia.

A facility-based cross-sectional study design was applied among 538 mothers with premature rapture of the membrane at Amhara region specialized hospitals. A simple random sampling technique was employed to select the medical charts diagnosed with all types of PROM and giving birth in the hospital within the period from July 8, 2019, to July 7, 2021. The data was collected using a checklist, entered into EPI Data version 3.1, and analyzed using SPSS version 23. A binary logistic regression model was used to see the association between independent and dependent variables. A P-value <0.05 was used to declare the statistical significance. The AOR with 95% CI was used to measure the strength of the association.

Adverse birth outcome among all types of Premature rupture of membrane mothers was 33.1% [95% CI 29.2–37.2]. Rural residents [AOR = 2.94, 95% CI:1.73–4.97], have a history of urinary tract infection [AOR = 6.87, 95% CI: 2.77–17.01], anemia [AOR = 7.51, 95% CI: 2.88–19.62], previous history of adverse birth outcome [AOR = 3.54, 95% CI: 1.32–9.47] and less than two years interpregnancy interval [AOR = 6.07, 95% CI: 2.49–14.77] were positively associated with adverse birth outcome compared to their counterparts.

The adverse birth outcome was high in the Amhara region as compared to the World Health Organization’s estimated figure and target; the target is less than 15%. History of the previous adverse birth outcome, residence, urinary tract infection, Anemia, and interpregnancy interval had an association with adverse birth outcomes. Therefore, strengthening close follow-up for mothers who had previous adverse birth outcomes, screening and treatment of urinary tract infection, anemia prevention, and maximizing birth interval are recommended for reducing adverse birth outcomes.