# Hyperviscosity Syndrome in Undifferentiated Connective Tissue Disease: A Diagnostic and Therapeutic Challenge

**Authors:** Ian Mines, Alaq Al-Abayechi, Supreet Kaur, Zohra Nooruddin

PMC · DOI: 10.7759/cureus.55399 · Cureus · 2024-03-02

## TL;DR

This paper discusses the challenges of diagnosing and treating hyperviscosity syndrome in a patient with an undetermined rheumatologic condition.

## Contribution

The paper presents a case emphasizing the diagnostic and therapeutic difficulties in hyperviscosity syndrome linked to undifferentiated connective tissue disease.

## Key findings

- Hyperviscosity can lead to severe complications like hypertension and cerebral vascular accidents.
- Identifying the underlying cause of hyperviscosity is more challenging than managing its acute effects.
- The case illustrates the complexity of diagnosing hyperviscosity in suspected rheumatologic disorders.

## Abstract

Hyperviscosity is an uncommon manifestation of various underlying diseases. Rapid diagnosis and management of the underlying disease is crucial to prevent significant complications, including hypertension, cerebral vascular accidents, pulmonary embolism, bowel ischemia, and ophthalmologic pathologies. Although the acute management of complications arising from hyperviscosity is relatively straightforward, identifying and treating the underlying cause can prove difficult. This case highlights the difficulties of establishing a diagnosis and initiating appropriate management for a patient with hyperviscosity syndrome in a suspected rheumatologic disorder.

## Linked entities

- **Diseases:** pulmonary embolism (MONDO:0005279), undifferentiated connective tissue disease (MONDO:0019527)

## Full-text entities

- **Diseases:** hypertension (MESH:D006973), rheumatologic disorder (MESH:D012216), cerebral vascular accidents (MESH:D020521), Hyperviscosity Syndrome (MESH:D013577), bowel ischemia (MESH:D007511), pulmonary embolism (MESH:D011655), Connective Tissue Disease (MESH:D003240)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10984367/full.md

## References

14 references — full list in the complete paper: https://tomesphere.com/paper/PMC10984367/full.md

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Source: https://tomesphere.com/paper/PMC10984367