# Eczema Herpeticum Complicating Atopic Dermatitis: A Rare Presentation

**Authors:** Mariana Pedro, Marta Caldas, Fernanda Neves, Sara Diogo, Fabiana Fortunato

PMC · DOI: 10.7759/cureus.55171 · 2024-02-28

## TL;DR

A rare case of eczema herpeticum in an infant with atopic dermatitis is reported, highlighting the importance of timely diagnosis and treatment.

## Contribution

This case report adds to the limited literature on eczema herpeticum in infants with atopic dermatitis.

## Key findings

- The infant presented with worsening skin lesions consistent with eczema herpeticum.
- Intravenous acyclovir treatment led to resolution of skin lesions after six weeks.
- Eczema herpeticum is rare but a serious complication of atopic dermatitis.

## Abstract

Atopic dermatitis (AD) has become a global health concern due to an increase in its frequency over the past few decades. This illness not only reduces the quality of life but also imposes a considerable financial burden due to the increased risk of skin infections.

This case report explores the presentation of a four-month-old male infant with a personal history of atopic dermatitis that developed yellow scaly lesions on the scalp, which were assumed to be cradle cap. However, there was a clinical worsening of the cutaneous lesions, with the appearance of vesicles, so he was referred to the Pediatric Emergency Room after an urgent dermatology appointment. A blood test was performed, which revealed severe eosinophilia and a slightly increased total IgE. Considering the patient's past medical record of atopic dermatitis and the observable characteristics of the skin rash, there was a strong suspicion of eczema herpeticum (EH). Consequently, intravenous acyclovir treatment was initiated, along with an antibiotic, as there were concerns about a potential secondary infection. He was followed up with a pediatric and dermatology appointment, with a resolution of skin lesions after six weeks.

EH is a rare clinical entity, usually caused by herpes simplex virus (HSV) types 1 and 2. It is a clinical entity that, while being uncommon, is one of the few dermatological emergencies responsible for a high morbidity rate, associated with the systemic spread of the viral infection.

## Linked entities

- **Diseases:** atopic dermatitis (MONDO:0004980)

## Full-text entities

- **Diseases:** EH (MESH:D007617), eosinophilia (MESH:D004802), viral infection (MESH:D014777), AD (MESH:D003876), dermatological emergencies (MESH:D000168), infection (MESH:D007239), vesicles (MESH:C567751), cutaneous lesions (MESH:D009059), skin lesions (MESH:D012871), skin rash (MESH:D005076)
- **Chemicals:** acyclovir (MESH:D000212)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10980554/full.md

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Source: https://tomesphere.com/paper/PMC10980554