# Paraneoplastic Syndrome Case Presented As Nystagmus and Ataxia

**Authors:** Khaled M Darwesh

PMC · DOI: 10.7759/cureus.55153 · 2024-02-28

## TL;DR

This paper discusses a case of paraneoplastic syndrome presenting as nystagmus and ataxia, highlighting the importance of detecting specific autoantibodies for diagnosis.

## Contribution

The paper presents a specific case that emphasizes the diagnostic criteria for paraneoplastic syndrome involving neurological symptoms and autoantibodies.

## Key findings

- Paraneoplastic syndrome can present with neurological symptoms like nystagmus and ataxia.
- Diagnosis requires concurrent cancer and detection of specific PNS autoantibodies.

## Abstract

The incidence of paraneoplastic syndrome (PNS) is on the rise, attributed to the growing detection of antibody modalities in both the serum and cerebrospinal fluid (CSF). PNS can occur as different neurological symptoms. The revised guidelines streamline the diagnostic approach but identifying PNS still requires the detection of neurological manifestations concurrent with cancer, along with the presence of specific PNS autoantibodies.

## Linked entities

- **Diseases:** paraneoplastic syndrome (MONDO:0021073)

## Full-text entities

- **Diseases:** Nystagmus (MESH:D009759), cancer (MESH:D009369), PNS (MESH:D010257), Ataxia (MESH:D001259), neurological symptoms (MESH:D009461)

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10980271/full.md

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Source: https://tomesphere.com/paper/PMC10980271