# Eosinophilic Pneumonia Induced by Daptomycin

## TL;DR

This paper reports a rare case of lung inflammation caused by a specific antibiotic, daptomycin, in a teenager with cancer.

## Contribution

The study highlights daptomycin-induced eosinophilic pneumonia as a rare but serious side effect in clinical practice.

## Key findings

- Daptomycin can cause eosinophilic pneumonia, marked by symptoms like dyspnea and blood eosinophilia.
- Diagnosis requires evaluating medical history, lab tests, and radiological findings.
- Treatment involves stopping daptomycin and using steroids in severe cases.

## Abstract

Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare but serious complication associated with the use of this broad-spectrum antibiotic. We present the case of a teenager with a history of nasopharyngeal cancer who developed DIEP while receiving daptomycin to treat an infection associated with an implanted chamber catheter. Symptoms included recurrent dyspnea and peripheral eosinophilia, with radiological findings consistent with DIEP. The pathophysiology involves an immune response triggered by daptomycin, resulting in eosinophilic pulmonary inflammation. Diagnosis requires a thorough evaluation of medical history, clinical laboratory tests, and radiological findings. The main treatment involves discontinuation of daptomycin and, in severe cases, the use of steroids. It is essential to consider DIEP in patients with respiratory failure and bilateral pulmonary opacities who have used daptomycin and to suspect it in those with blood eosinophilia or in bronchoalveolar lavage.