# Anti-SARS-CoV-2 Vaccination and PIMS-TS—Friends or Foe? Case Reports and Literature Review

## TL;DR

This paper explores whether anti-SARS-CoV-2 vaccination is safe for children who had PIMS-TS, a rare inflammatory condition linked to SARS-CoV-2.

## Contribution

The study contributes case reports and a literature review on vaccination safety in PIMS-TS patients.

## Key findings

- Three PIMS-TS patients were safely vaccinated against SARS-CoV-2 after recovery.
- One PIMS-TS patient developed the condition temporarily after vaccination.
- Data from multiple centers were reviewed to assess vaccination safety in this group.

## Abstract

Pediatric inflammatory, multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS), also known as a multisystem inflammatory syndrome in children (MIS-C), is diagnosed in children who develop an inadequate inflammatory response after exposure to the SARS-CoV-2 virus. The pathogenesis of the abnormal response of the immune system to a previous SARS-COV-2 infection has not been explained. Similarly, the safety and effectiveness of COVID-19 vaccinations in this group of patients have become the subject of clinical discussion. Presenting experiences from many centers aims to answer this question. We present 4 cases of patients who suffered from PIMS-TS. Three of them were safely vaccinated against COVID-19 after illness. One patient developed PIMS-TS temporarily associated with COVID-19 vaccination. We also collected and discussed data from other centers.