# An Unusual Case of Hemothorax in an Ehlers-Danlos Syndrome Patient Following Sildenafil Use

**Authors:** Ashwin Varkey, Katherine Killian, Jillian Melnick

PMC · DOI: 10.7759/cureus.55084 · Cureus · 2024-02-27

## TL;DR

A patient with Ehlers-Danlos syndrome developed hemothorax after using sildenafil, highlighting the need for careful medication prescriptions.

## Contribution

Highlights a rare complication of sildenafil use in Ehlers-Danlos syndrome patients.

## Key findings

- A patient with Ehlers-Danlos syndrome developed hemothorax following sildenafil use.
- Surgical treatment led to recovery, emphasizing the importance of thorough patient evaluation before prescribing medications.

## Abstract

Ehlers-Danlos syndrome is a disorder of collagen production that affects the connective tissues of the body. It can cause several conditions and severely affect patients' quality of life and activities of daily living. Here, we present an unusual case of hemothorax in a patient with Ehlers-Danlos syndrome after sildenafil use. This manifested in shortness of breath and cough and prompted the patient to visit the emergency room. The hemothorax was treated surgically, and the patient recovered well. Sildenafil was initially prescribed via a telemedicine service without in-person consultation. It is important that physicans perform a thorough history and physical examination prior to prescribing medications to patients, especially those at risk for complications.

## Linked entities

- **Chemicals:** sildenafil (PubChem CID 135398744)
- **Diseases:** Ehlers-Danlos syndrome (MONDO:0020066)

## Full-text entities

- **Diseases:** Hemothorax (MESH:D006491), cough (MESH:D003371), Ehlers-Danlos Syndrome (MESH:D004535), collagen (MESH:D003095), shortness of breath (MESH:D004417)
- **Chemicals:** Sildenafil (MESH:D000068677)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC10974947/full.md

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Source: https://tomesphere.com/paper/PMC10974947