# Postpartum Onset of Multiple Sclerosis: A Case Report

**Authors:** Catarina Afonso, Luís Bicheiro, Marta Lopes

PMC · DOI: 10.7759/cureus.54972 · Cureus · 2024-02-26

## TL;DR

A 29-year-old woman developed multiple sclerosis symptoms three months postpartum, highlighting the need for careful diagnosis in postpartum care.

## Contribution

This case report highlights the rare onset of multiple sclerosis in the postpartum period and emphasizes the importance of early diagnosis.

## Key findings

- A postpartum woman exhibited symptoms consistent with multiple sclerosis, including vertigo and limb weakness.
- MRI findings suggested primary demyelinating lesions, leading to a referral for MS evaluation.
- The case emphasizes the importance of timely diagnosis in postpartum women to improve disease prognosis.

## Abstract

A breastfeeding 29-year-old woman who gave birth to her first child three months ago presented at the family doctor’s appointment with a diverse array of symptoms, including vertigo, blurred vision, right lower limb weakness, and abdominal allodynia. She has a history of obesity and anxiety. The patient had a pre-pregnancy history of several visits to the family doctor. She takes folic acid, vitamin B12, iodine, and omega-3 supplements. The diverse symptomatology, the patient’s insistence on seeking medical care, and the history of anxiety pose significant hurdles in arriving at a timely diagnosis. Magnetic resonance imaging showed signs compatible with primary demyelinating lesions of the central nervous system, which elicited a referral to neurology. The clinical and imagiological findings were suggestive of multiple sclerosis (MS), for which a conservative approach was taken.

MS is a chronic inflammatory autoimmune disease with a mean age of onset of 20-30 years, more common in females. Stressful life events, viral infections, vaccination, physical trauma, previous anesthesia, excessive physical activity, and puerperium have all been described as trigger factors.

This case underscores the importance of vigilance in postpartum healthcare and the importance of conducting a comprehensive diagnostic assessment. Early diagnosis has a positive impact on the prognosis of the disease.

## Linked entities

- **Chemicals:** folic acid (PubChem CID 135398658), vitamin B12 (PubChem CID 73415824), iodine (PubChem CID 807), omega-3 (PubChem CID 1548943)
- **Diseases:** multiple sclerosis (MONDO:0005301), anxiety (MONDO:0005618), obesity (MONDO:0011122)

## Full-text entities

- **Diseases:** anxiety (MESH:D001007), trauma (MESH:D014947), MS (MESH:D009103), obesity (MESH:D009765), abdominal allodynia (MESH:D000007), viral infections (MESH:D014777), lower limb weakness (MESH:D018908), primary demyelinating lesions of the central nervous system (MESH:D003711), inflammatory (MESH:D007249), blurred vision (MESH:D014786), vertigo (MESH:D014717), autoimmune disease (MESH:D001327)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC10972609/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC10972609/full.md

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Source: https://tomesphere.com/paper/PMC10972609