# A Seasonal Variation of Clinical and Neurological Outcomes in Patients with Out-of-Hospital Cardiac Arrest Treated with Extracorporeal Cardiopulmonary Resuscitation: A Secondary Data Analysis of the SaveJ II Study

## TL;DR

This study found no seasonal differences in survival or neurological outcomes for cardiac arrest patients treated with extracorporeal resuscitation.

## Contribution

The study is the first to investigate seasonal variation in outcomes for OHCA patients treated with ECPR.

## Key findings

- No significant seasonal differences in in-hospital mortality for OHCA patients treated with ECPR.
- Favorable neurological outcomes were not significantly affected by seasonal factors.
- Multivariable analysis confirmed no association between season and clinical or neurological outcomes.

## Abstract

The prognosis for patients with out-of-hospital cardiac arrest (OHCA) has been reported to be worse in the cold season. On the other hand, it is unclear whether a similar trend exists in OHCA patients who are treated with extracorporeal cardiopulmonary resuscitation (ECPR). This study was a retrospective multicenter registry study. We examined the association between ECPR and season. We compared the prognosis in four seasonal groups according to the day of occurrence. Multivariable logistic regression analysis was performed for the assessment of clinical and neurological outcomes. A total of 2024 patients with OHCA who received ECRP were included. There were no significant differences in in-hospital mortality (p = 0.649) and in the rate of favorable neurological outcome (p = 0.144). In the multivariable logistic regression, the seasonal factor was not significantly associated with worse in-hospital mortality (p = 0.855) and favorable neurological outcomes (p = 0.807). In this study, there was no seasonal variation in OHCA patients with ECPR.