# Translation of Data from Animal Models of Cancer to Immunotherapy of Breast Cancer and Chronic Lymphocytic Leukemia

## TL;DR

This paper reviews how research using animal models has contributed to the development of immunotherapies for breast cancer and leukemia.

## Contribution

The paper highlights novel insights from animal models that have directly influenced human cancer immunotherapy.

## Key findings

- Animal models, including gene-modified mice, have provided critical data for immunotherapy development.
- Studies on breast cancer and lymphoma models have shown translational success in human treatments.
- Collaborative research has demonstrated the impact of preclinical findings on clinical outcomes.

## Abstract

The field of clinical oncology has been revolutionized over the past decade with the introduction of many new immunotherapies the existence of which have depended to a large extent on experimentation with both in vitro analysis and the use of various animal models, including gene-modified mice. The discussion below will review my own laboratory’s studies, along with those of others in the field, on cancer immunotherapy. Our own studies have predominantly dwelt on two models of malignancy, namely a solid tumor model (breast cancer) and lymphoma. The data from our own laboratory, and that of other scientists, highlights the novel information so obtained, and the evidence that application of such information has already had an impact on immunotherapy of human oncologic diseases