# Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation

## TL;DR

Chlorogenic acid, a compound from a traditional Chinese herb, helps prevent bone loss in postmenopausal conditions by boosting bone-building cells and reducing bone-breaking cells.

## Contribution

The study identifies chlorogenic acid as a promising molecule for anti-osteoporosis treatment through its dual effects on osteoblasts and osteoclasts.

## Key findings

- Chlorogenic acid enhances osteoblast proliferation and differentiation.
- Chlorogenic acid inhibits RANKL-induced osteoclastogenesis.
- Administration of chlorogenic acid reduces ovariectomy-induced bone loss in rats.

## Abstract

Osteoporosis is a usual bone disease in aging populations, principally in postmenopausal women. Anti-resorptive and anabolic drugs have been applied to prevent and cure osteoporosis and are associated to a different of adverse effects. Du-Zhong is usually applied in Traditional Chinese Medicine to strengthen bone, regulate bone metabolism, and treat osteoporosis. Chlorogenic acid is a major polyphenol in Du-Zhong. In the current study, chlorogenic acid was found to enhance osteoblast proliferation and differentiation. Chlorogenic acid also inhibits the RANKL-induced osteoclastogenesis. Notably, ovariectomy significantly decreased bone volume and mechanical properties in the ovariectomized (OVX) rats. Administration of chlorogenic acid antagonized OVX-induced bone loss. Taken together, chlorogenic acid seems to be a hopeful molecule for the development of novel anti-osteoporosis treatment.