Senescence Promotes the Recovery of Stemness among Cancer Cells via Reprograming

TL;DR

This paper explores how senescence in cancer cells can lead to the recovery of stem-like properties through reprogramming.

Contribution

The novelty lies in highlighting the reprogramming of senescent cancer cells to regain stemness, challenging traditional views.

Findings

Senescence and stemness in cancer cells are linked through shared signaling pathways.

Senescent cancer cells can reprogram to recover stemness in various tumor systems.

Abstract

Both the senescence of cancer cells and the maintenance of cancer stem cells seem to be mutually exclusive because senescence is considered a physiological mechanism that effectively suppresses tumor growth. Recent studies have revealed common signaling pathways between cellular senescence and the maintenance of stemness in cancer cells, thus challenging the conventional understanding of this process. Although the links between these processes have not yet been fully elucidated, emerging evidence indicates that senescent cancer cells can undergo reprograming to recover stemness. Herein, we provide a comprehensive overview of the close correlation between senescence and stemness reprograming in cancer cells, with a particular focus on the mechanisms by which senescent cancer cells recover their stemness in various tumor systems.

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