# Analysis of the effect of changes in serum osteopontin levels on patients with acute cerebral infarction

## TL;DR

This study found that higher levels of a protein called osteopontin in the blood are linked to worse outcomes in patients with acute cerebral infarction.

## Contribution

The study identifies serum osteopontin as a potential biomarker for predicting disease severity and prognosis in acute cerebral infarction.

## Key findings

- Serum osteopontin levels were significantly higher in patients with acute cerebral infarction compared to healthy controls.
- Higher osteopontin levels on day seven were an independent risk factor for poor prognosis in cerebral infarction.
- Osteopontin levels correlated with disease severity and infarct size in patients.

## Abstract

To investigate the correlation of serum osteopontin levels with disease severity and prognosis in patients with acute cerebral infarction.

This retrospective analysis included forty patients with acute cerebral infarction (ACI) admitted to the Department of Neurology of Baoding Children’s Hospital from May, 2019 to May, 2022 within 24 hours of onset were selected as the observation group, while 40 healthy subjects in our hospital during the same period were selected as the control group. The correlation between serum Osteopontin (OPN) levels and risk factors on one day, seven days and 14 days was analyzed. Patients in the observation group were subdivided into the good prognosis group and the poor prognosis group according to mRS score, and the serum OPN levels of the two groups were compared. The correlation between serum OPN and disease severity and prognosis of patients with ACI was analyzed.

The serum OPN levels in the observation group were significantly higher than those in control group (P< 0.05), and its level was positively correlated with NIHSS score and infarct size. The proportion of patients with hyperlipidemia, smoking, drinking, hypertension and OPN level on seven day in the poor prognosis group were higher than those in the good prognosis group (P<0.05). The OPN level > 8.720 ng/ml on seven days was an independent risk factor for poor prognosis of cerebral infarction.

OPN is involved in the entire pathophysiological process of ACI, and its level can predict the severity of the disease in patients with ACI, and can be used as an important indicator for evaluating their clinical prognosis.