# Comparison of efficacy of daily and alternate day maintenance treatment of GERD with Vonoprazan 10-mg using Gastroesophageal Reflux Disease Symptom Assessment Scale

## TL;DR

This study found that taking Vonoprazan 10-mg every other day is just as effective as daily use for managing GERD symptoms over two weeks.

## Contribution

The study introduces evidence that alternate-day dosing of Vonoprazan is non-inferior to daily dosing for GERD maintenance.

## Key findings

- GSAS scores significantly improved from week-0 to week-2 in both groups.
- No significant difference in symptom scores between daily and alternate-day dosing at week-2.
- Alternate-day Vonoprazan 10-mg is equally effective as daily dosing for GERD maintenance.

## Abstract

To compare efficacy of 10-mg of vonoprazan daily & on alternate days by Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS)

This prospective interventional cohort was done at Department of Medicine/Gastroenterology Dow Medical College, Karachi, Pakistan during the period August 2022 & January 2023. Potential participants fulfilling inclusion and exclusion criteria were asked to fill out GSAS questionnaires after their written consent. Patients were allocated in to two groups using random tables. Group-A was given Tab Vonoprazan 10-mg daily for two weeks. Group-B was given Tab Vonoprazan 10-mg on alternate day. GSAS was scored by totaling scores across symptoms and then they are divided by the total number of non-missing symptom scores. Both groups were assessed week-0 & week-2.

Only 90 proformas that were completely filled were included, Group-A had 30 males and 15 females while Group-B had 29 males and 16 females. No significant difference in score was found in GSAS score at week-0 except that in item ‘gurgling’ while at week two there was no significant difference between any of the items. Total GSAS score were significantly lower at Week-2 than at week-0 (p = <.001).

Vonoprazan of 10-mg on alternate day is equally effective as 10-mg daily in maintenance of GERD patients at two weeks.