# Patient with a novel syndrome with multiple benign hepatic lesions and extrahepatic neoplasms

## TL;DR

This paper reports a rare case of a patient with multiple benign liver tumors and other cancers, along with a new mutation and unusual cell features.

## Contribution

First reported case of a syndrome with three benign liver tumors and a novel mutation, plus new histopathological findings.

## Key findings

- First clinical case of a syndrome with three benign liver tumors and a novel mutation.
- Liver adenoma cells showed expression of cytokeratin 7, a new histopathological observation.
- Presence of extrahepatic neoplasms suggests a broader underlying genetic syndrome.

## Abstract

Simultaneous occurrence of benign hepatic lesions of different types is a sporadic phenomenon. To the best of our knowledge, we report the first clinical case of a syndrome with simultaneous manifestations of three different entities of benign liver tumors (hepatocellular adenoma, focal nodular hyperplasia and hemangioma) with a novel mutation detected in the liver adenoma and in the presence of a number of further extrahepatic organ neoplasms. Furthermore, we describe for the first time the presence of liver epithelial cells of hepatocytic phenotype expressing cytokeratin 7 (CK7) at the border of the adenoma. These findings may be important for explaining pathogenesis of benign as well as malignant tumors based on genetic and histopathological features.