# Extramedullary Imaging Manifestations of Leukemia/Lymphoblastic Lymphoma in Pediatrics: A Case Series

## TL;DR

This paper presents four pediatric cases of B-cell lymphoblastic leukemia with extramedullary symptoms, highlighting their imaging and clinical features for better diagnosis.

## Contribution

The study provides a case series of extramedullary B-cell lymphoblastic leukemia in children, emphasizing imaging patterns for early diagnosis.

## Key findings

- Four pediatric patients showed extramedullary manifestations of B-cell lymphoblastic leukemia.
- Clinical and imaging features helped identify a distinct presentation pattern in these cases.
- Histopathological confirmation supported the imaging-based diagnosis in all cases.

## Abstract

Leukemia is the most common childhood malignancy and often presents with nonspecific symptoms. Occasionally, it presents with extramedullary manifestations, which have been more frequent in cases of myeloid lineage or T cells. However, precursor B-cell leukemia/lymphoblastic lymphoma can also have extramedullary manifestations in some patients. Describing certain clinical features along with diagnostic imaging can establish a presentation pattern and suggest a diagnosis in the pediatric population. Herein, we present a series of four patients with extramedullary manifestations of B-cell lymphoblastic leukemia, describing their clinical imaging and histopathological characteristics.