# Anti-MDA5 Antibody-Positive Clinically Amyopathic Dermatomyositis Associated With Multiple Heterologous Carcinomas: A Case Report

## TL;DR

A man with a rare skin and lung condition developed two cancers, highlighting the need for regular cancer screenings in similar cases.

## Contribution

This case report emphasizes the importance of periodic cancer screening in anti-MDA5-positive CADM patients.

## Key findings

- A patient with anti-MDA5-positive CADM developed gastric and colorectal cancers.
- Early endoscopic screening led to successful cancer resections and prevented recurrence.
- The case suggests a need for vigilance and regular cancer monitoring in CADM patients.

## Abstract

Dermatomyositis (DM), an autoimmune disorder, is linked to increased malignancy risk. A 53-year-old man with anti-melanoma differentiation-associated gene 5 (MDA5)-positive clinically amyopathic dermatomyositis (CADM) and rapidly progressing interstitial lung disease (RP-ILD) developed heterochronous gastric and colorectal cancers. Early endoscopic screenings led to successful curative resections, preventing recurrence. Despite low cancer incidence assumptions in patients with anti-MDA5-positive RP-ILD, this case advocates for reevaluation and periodic cancer screenings to enhance management, considering the improved survival with intensive therapy. Vigilance for multiple carcinomas at various time points is vital in CADM management.