# Acute Mesenteric Ischemia Secondary to Candida Endocarditis: A Case Report

## TL;DR

A 36-year-old man developed acute bowel and organ damage from a rare fungal infection of the heart, which was successfully treated with surgery and antifungal drugs.

## Contribution

This is the first reported case of acute mesenteric ischemia caused by Candida endocarditis.

## Key findings

- Acute mesenteric ischemia was caused by a fungal infection of the heart valve (Candida tropicalis).
- The patient recovered after surgical valve replacement and antifungal therapy.
- Clinicians should consider infective endocarditis as a cause of mesenteric ischemia in patients without traditional risk factors.

## Abstract

A 36-year-old man presented with abdominal pain, vomiting, and diarrhea. On arrival, his vital signs were remarkable for fever (39.3 °C) and tachycardia (127 beats/min, regular). His abdomen was distended, and a blood test showed elevations of inflammatory markers. Contrast-enhanced computed tomography revealed a superior mesenteric artery thrombus, ischemic colitis, ascites, and infarctions in the spleen and right kidney. He was diagnosed with bowel necrosis due to acute mesenteric ischemia (AMI). An emergent laparotomy was performed. The following day, Candida tropicalis was identified in the blood culture. In addition, transthoracic echocardiography revealed vegetation on the mitral valve leaflet. These findings were suggestive of infective endocarditis (IE) caused by C. tropicalis (Candida endocarditis); thus, the patient underwent surgical mitral valve replacement with the administration of antifungal therapy. Following postoperative intensive care and a prolonged course of antifungal treatment, he achieved a full recovery. AMI is only rarely caused by IE, and this case is the first reported instance of AMI secondary to Candida endocarditis. When encountering patients with AMI without any risk factors for thromboembolism, clinicians should be aware that IE may cause AMI.