# An OLD protein teaches us new tricks: prokaryotic antiviral defense

**Authors:** Eirene Marie Q. Ednacot, Benjamin R. Morehouse

PMC · DOI: 10.1038/s41467-024-46925-1 · 2024-03-21

## TL;DR

Scientists discovered how a bacterial protein system called Gabija helps fight viruses by forming specific structures.

## Contribution

The study reveals the 3D structures of Gabija and confirms protein assembly is key for its antiviral role.

## Key findings

- Gabija's three-dimensional structures were determined using advanced techniques.
- Protein assembly formation is essential for the system's antiviral function.
- The findings support recent studies on bacterial immune defense mechanisms.

## Abstract

Reporting in Nature Communications, Huo and colleagues provide three-dimensional structures of a bacterial immune defense system called Gabija. This work builds on recently published structural and functional studies and contributes strong evidence that protein assembly formation is essential for antiviral function.

## Full-text entities

- **Genes:** ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)) [NCBI Gene 10058] {aka ABC, LAN, MTABC3, PRP, umat}, DNAH8 (dynein axonemal heavy chain 8) [NCBI Gene 1769] {aka ATPase, SPGF46, hdhc9}
- **Diseases:** fire (MESH:D000092422), infection (MESH:D007239)
- **Chemicals:** gold (MESH:D006046), ATP (MESH:D000255), Gabija (-), dGTP (MESH:C029603), nucleotide (MESH:D009711), GTP (MESH:D006160), dATP (MESH:C026600)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC10957863/full.md

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Source: https://tomesphere.com/paper/PMC10957863