# Acute Cytomegalovirus Infection Associated With Erythema Multiforme-Like Eruption: A Case Report

## TL;DR

A rare case of cytomegalovirus infection presented with a skin rash and fever, resolving without antiviral treatment.

## Contribution

Reports a rare case of CMV infection with erythema multiforme-like eruption in an immunocompetent patient.

## Key findings

- Cytomegalovirus DNA was detected in the patient's blood sample.
- The clinical symptoms resolved without antiviral therapy.
- The diagnosis was confirmed through specific serology.

## Abstract

Human cytomegalovirus infection usually proceeds asymptomatically in immunocompetent patients. In symptomatic forms, mononucleosis syndrome is the most common manifestation. However, atypical cases of cytomegalovirus infections in immunocompetent subjects are reported in the literature. Here, we describe a case of cytomegalovirus-related mononucleosis syndrome that presented with an atypical erythema multiforme-like skin rash and high fever. Very few cases have been described in the literature previously. In our case, the diagnosis was supported by specific serology, and human cytomegalovirus DNA was detected in the blood sample. The clinical picture resolved without the administration of antiviral therapy.