# Studies on clinicopathological features of duodenal-type follicular lymphoma of 18 patients

## TL;DR

This study examines the clinical and pathological features of duodenal-type follicular lymphoma in 18 patients, finding it to be a slow-growing cancer with a good prognosis.

## Contribution

The study provides new clinical and pathological insights into a rare subtype of follicular lymphoma originating in the duodenum.

## Key findings

- D-FL is a low-grade lymphoma with a median age of 49 years and a predominantly female-to-male ratio.
- Patients showed gastrointestinal symptoms and endoscopic features like multiple gray-white polypoid lesions.
- The tumor exhibited a favorable prognosis with no need for chemotherapy or targeted therapy in observed cases.

## Abstract

为研究十二指肠型滤泡性淋巴瘤（duodenal-type follicular lymphoma，D-FL）的临床及病理学特点，总结2020年1月至2023年7月期间首都医科大学附属北京天坛医院病理科会诊及本院确诊的18例D-FL患者的临床症状、内镜特点、病理形态学特点、免疫表型、分子病理特征以及治疗随访经过。18例D-FL患者，男10例，女8例，中位年龄为49（32～69）岁。患者多为胃肠镜检查发现或出现常见胃肠道症状，如胃痛、反酸、呕吐及腹泻。内镜大多表现为多发灰白色小息肉样隆起。病理形态学上为黏膜层及黏膜下层可见淋巴滤泡样结构。免疫表型为肿瘤细胞广泛强表达CD20及BCL2，增殖活性低。免疫球蛋白克隆分析显示1例IgK单克隆重排（1/1），FISH检测1例BCL2基因重排（1/3）。所有患者均未进行靶向及化疗，采取等待及观望策略。中位随访12（2～34）个月。研究显示D-FL属于惰性淋巴瘤，好发于十二指肠，预后良好。