# Blastic plasmacytoid dendritic cell tumor treated with DVT regimen：a case report and literature review

## TL;DR

A rare aggressive blood cancer was successfully treated in an elderly patient using a new drug combination that caused complete remission with fewer side effects.

## Contribution

The DVT regimen (decitabine, venetoclax, thalidomide) shows promising efficacy and safety for treating BPDCN in elderly patients.

## Key findings

- The DVT regimen achieved complete remission in an 85-year-old BPDCN patient.
- The treatment was well-tolerated and effective in patients unable to undergo intensive chemotherapy.
- IDH2 and ASXL1 mutations were identified in the patient's tumor.

## Abstract

母细胞性浆细胞样树突细胞肿瘤（BPDCN）是一种罕见的具有高度侵袭性的血液系统恶性肿瘤，目前无统一治疗方案，预后极差。大连大学附属中山医院报道1例85岁BPDCN男性患者应用DVT方案（地西他滨联合维奈克拉、沙利度胺）治疗获完全缓解的病例。患者皮肤结节起病，病理提示BPDCN，皮肤结节二代测序提示IDH2、ASXL1热点突变。地西他滨联合维奈克拉、沙利度胺的DVT非化疗治疗方案对于BPDCN疗效显著，起效快，缓解程度深，安全性好，尤其适用于无法耐受强化疗的老年患者。