Expression of Concern: Molecular Characterization of Severin from Clonorchis sinensis Excretory/Secretory Products and Its Potential Anti-apoptotic Role in Hepatocarcinoma PLC Cells
Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsParasites and Host Interactions · Pharmacological Effects and Toxicity Studies
The following concerns were raised about Figs 3 and 5 of this article [1]:
Corresponding author YH stated that the original data underlying the results reported in this article are no longer available, and so the above issues cannot be resolved.
In addition, the study reports the use of “human normal hepatocyte L-02” cells in flow cytometry experiments shown in Fig 6B. Following the publication of this article [1], the L-02 cell line was identified as contaminated and shown to be a HeLa derivative instead [2]. Therefore, the results statements in [1] about effects of rCsseverin on human normal hepatocyte cells are not supported, although this may not critically impact the PLC cell results reported in Fig 6A.
The PLOS Neglected Tropical Diseases Editors issue this Expression of Concern to inform readers of these unresolved issues. Readers should interpret the results of the affected figures with caution.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Chen X, Li S, He L, Wang X, Liang P, Chen W, et al. (2013) Molecular Characterization of Severin from Clonorchis sinensis Excretory/Secretory Products and Its Potential Anti-apoptotic Role in Hepatocarcinoma PLC Cells. P Lo S Negl Trop Dis 7(12): e 2606. 10.1371/journal.pntd.000260624367717 PMC 3868641 · doi ↗ · pubmed ↗
- 2Ye F, Chen C, Qin J, Liu J, Zheng C (2015) Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China. FASEB J 29(10):4269–72. doi: 10.1096/fj.14-266718 26116706 · doi ↗ · pubmed ↗