# Use of phthalocyanine-derived mouthwash as a protective factor for COVID-19: a community trial

## TL;DR

A community trial found that using a phthalocyanine-based mouthwash reduced the risk of COVID-19, especially among those without high school education.

## Contribution

This study demonstrates that phthalocyanine-derived mouthwash offers a protective effect against SARS-CoV-2 infection.

## Key findings

- Daily use of phthalocyanine mouthwash provided a 14.1% protective factor against COVID-19.
- Individuals without high school education used the mouthwash significantly more frequently.
- Survival rates correlated with the duration of APD use.

## Abstract

In a population profile corrected for sociodemographic factors, the aim of this study was to examine sociodemographic the protective effect of a phthalocyanine-derived mouthwash (APD) before infection with SARS-CoV-2, in addition to analyzing the survival of the at-risk population and the confirmed diagnosis of COVID-19.

For individuals from the Uru municipality, a structured questionnaire consisting of two parts was completed before the distribution of APD. Subsequently, subjects received two bottles containing 600 mL of APD and were instructed to rinse/gargle with 3 mL of the solution 3 to 5 times per day for 1 min for 2 months. Data were obtained from the electronic system of the municipal health center, organized in a spreadsheet, and analyzed using multiple linear regression and Cox regression analysis.

The study included 995 participants with the following sociodemographic data: 98/995 individuals (p<0.002) who did not complete high school used the APD 66.30 times more than did individuals with higher education. The results in terms of survival were meaningful in relation to the duration of APD use. The protective factor for COVID-19 was 14.1%.

Daily use of a solution containing phthalocyanine derivatives provided a higher protection factor against COVID-19 infection, predominantly in individuals without a school-completion certificate.