# Association Between Head Computed Tomography Findings and In-Hospital Mortality in COVID-19 Patients

## TL;DR

This study found that low-density lesions in the basal ganglia on head CT scans are linked to higher in-hospital mortality and longer hospital stays in COVID-19 patients.

## Contribution

The study identifies low-density lesions in the basal ganglia as a novel prognostic indicator for mortality in hospitalized COVID-19 patients.

## Key findings

- Low-density lesions in the basal ganglia were significantly associated with increased in-hospital mortality.
- Patients with low-density lesions in the basal ganglia had prolonged hospital stays.
- The study used multivariable regression to adjust for patient background and disease severity.

## Abstract

Objective: The present study investigated the association between head computed tomography (CT) findings and mortality in patients with COVID-19. Specifically, we focused on low-density lesions identified on head CT screenings.

Materials and methods: We performed a single-center, retrospective cohort study based on data obtained from the medical charts of inpatients admitted to the Tokyo Metropolitan Hiroo Hospital between January 1 and December 31, 2021. We focused on the basal ganglia--a representative anatomical region for assessing routine head CT in patients with COVID-19. Patients were divided into two groups based on the presence or absence of low-density lesions in the basal ganglia. The primary outcome was all-cause in-hospital mortality, and the secondary outcome was the length of hospital stay. We performed multivariable regression analyses for outcomes to adjust for patients’ background and disease severity.

Results: During the study period, 1,906 COVID-19 patients were admitted to our facility. Among them, 1,203 patients underwent head CT evaluations and were included in this study. The median age was 56 years (interquartile range: 43-76 years) and 725 patients (60.3%) were male. A total of 235 (19.5%) patients required oxygen therapy on admission and 1,051 (87.4%) patients had pneumonia. Crude in-hospital mortality was 6.1% and the median length of hospital stay was 10 days (interquartile range: 8-14 days). The multivariate regression analyses showed that low-density lesions in the basal ganglia were significantly associated with increased in-hospital mortality and prolonged hospital stay.

Conclusions: The presence of ischemic changes in the basal ganglia denoted by low-density findings may be a promising prognostic factor in patients with COVID-19.