# Bronchodilator reversibility testing in morbidly obese non-smokers: a comparative study– few concerns

**Authors:** Divya Balan, Manish R Shetty, Manu K Mohan

PMC · DOI: 10.1186/s12890-024-02951-9 · 2024-03-15

## TL;DR

This letter questions the value of a combination medication for bronchodilator testing in non-smokers with morbid obesity.

## Contribution

The letter highlights that the combination medication did not provide new insights beyond standard benchmarks.

## Key findings

- Both salbutamol and Fluticasone/salmeterol met the 12%- and 200-mL FEV1 reversibility benchmarks.
- The combination medication did not offer novel benefits over salbutamol.

## Abstract

This is a letter in response to an article by Ahmed et al., which concluded that in comparison to salbutamol, Fluticasone/salmeterol combination increases FEV1, FEV1% of predicted, and FEV1/FVC ratio, however it did not offer novel insights, as both agents met the 12%- and 200-mL reversibility benchmarks and Concerns about incorporating a combination medication that includes an inhaled corticosteroid, inhaled corticosteroids are not typically associated with bronchodilation.

## Linked entities

- **Chemicals:** Fluticasone (PubChem CID 5311101), salmeterol (PubChem CID 5152), salbutamol (PubChem CID 2083)

## Full-text entities

- **Diseases:** obese (MESH:D009765)
- **Chemicals:** salmeterol (MESH:D000068299), Fluticasone (MESH:D000068298), salbutamol (MESH:D000420)

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Source: https://tomesphere.com/paper/PMC10943866