Correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma: A meta-analysis and trial sequential analysis
Delin Wu, Yuna Liu, Yan Liu, Najuan Cui, Yan Zhu, Sidao Zheng, Shaohua Wang
TL;DR
This study uses a meta-analysis to explore if a genetic variation in LTC4S is linked to increased asthma risk.
Contribution
The study provides updated evidence on the LTC4S -444 A>C polymorphism's role in asthma susceptibility through comprehensive data synthesis.
Findings
The LTC4S -444 A>C polymorphism is significantly associated with asthma susceptibility.
Meta-analysis results suggest a consistent correlation across multiple studies.
Trial sequential analysis confirms the robustness of the observed association.
Abstract
This study aims to uncover the potential correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma. Literatures reporting the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma published before 1st June, 2019 were searched in PubMed, Embase, Cochrane, Wanfang and CNKI. Eligible literatures were enrolled and their data were extracted. OR and its 95% CI were calculated for assessing the correlation between LTC4S -444 A>C polymorphism and susceptibility to asthma. The included data were weighted by an inverse variance and then analyzed by a fixed or random effects model. Heterogeneity test and sensitivity analysis were performed on the enrolled reports. STATA12.1 and TSA (trial sequential analysis) were utilized for analyses.
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Taxonomy
TopicsAsthma and respiratory diseases · Respiratory and Cough-Related Research · Allergic Rhinitis and Sensitization