A Case of Pan-TRK Positive Dermatofibrosarcoma Protuberans Located on the Nose

TL;DR

A rare case of a facial tumor showed pan-TRK positivity, suggesting TRK inhibitors could be effective for such tumors.

Contribution

Reports a unique case of pan-TRK-positive DFSP on the nose with NTRK fusion detected via immunostaining.

Findings

Pan-TRK positivity was detected in DFSP located on the nasal dorsum of a 46-year-old female.

NTRK fusion gene involvement was confirmed through histological analysis and pan-TRK immunostaining.

The case suggests TRK inhibitors may be effective for treating pan-TRK-positive DFSP in facial regions.

Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare and infiltrative soft tissue tumor. Our report details a distinctive case of DFSP with pan-TRK positivity in the right nasal dorsum of a 46-year-old female. Histological analysis identified NTRK fusion gene involvement in this patient, detectable through pan-TRK immunostaining. The case underscores the significance of comprehensive management for pan-TRK-positive DFSP in challenging facial locations, indicating the potential efficacy of TRK inhibitors.

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