Lestaurtinib potentiates TRAIL‐induced apoptosis in glioma via CHOP‐dependent DR5 induction

TL;DR

This retracted study claimed that lestaurtinib enhances TRAIL-induced cell death in glioma through DR5 induction, but its findings are unreliable due to image duplication.

Contribution

The paper originally proposed a novel mechanism involving CHOP-dependent DR5 upregulation to enhance glioma cell apoptosis.

Findings

Lestaurtinib was reported to increase TRAIL-induced apoptosis in glioma cells.

The effect was suggested to depend on CHOP-mediated DR5 induction.

Findings were found to be compromised due to duplicated images.

Abstract

Yingxiao Cao, Shiqi Kong, Yuling Xin, Yan Meng, Shuling Shang, Yanhui Qi. Lestaurtinib potentiates TRAIL‐induced apoptosis in glioma via CHOP‐dependent DR5 induction. J Cell Mol Med. 2020; 24: 7829–7840. https://doi.org/10.1111/jcmm.15415.

The above article, published online on 22 May 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor‐in‐Chief, Stefan Constantinescu, The Foundation for Cellular and Molecular Medicine, and John Wiley and Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed inappropriate duplications of images between this and other articles that were either previously published or published later in the same year in a different scientific context. Thus, the editors consider the conclusions of this manuscript substantially compromised.