# Risk factors and related miRNA phenotypes of chronic pain after thoracoscopic surgery in lung adenocarcinoma patients

## TL;DR

This study identifies risk factors and specific miRNA patterns linked to chronic pain after lung cancer surgery, which could help in developing better pain management strategies.

## Contribution

The study identifies novel miRNA biomarkers and clinical risk factors for chronic postsurgical pain in lung adenocarcinoma patients.

## Key findings

- Chronic pain after surgery is associated with higher BMI, preoperative chronic pain history, and specific miRNA expression changes.
- miRNA 550a-3p, miRNA 3613-3p, and lower miRNA 146a-3p are linked to chronic pain development.
- Body mass index and miRNA 550a-3p are independent risk factors for chronic postsurgical pain.

## Abstract

Chronic postsurgical pain may have a substantial impact on patient’s quality of life, and has highly heterogenous presentation amongst sufferers. We aimed to explore the risk factors relating to chronic pain and the related miRNA phenotypes in patients with lung adenocarcinoma after video-assisted thoracoscopic lobectomy to identify potential biomarkers. Our prospective study involved a total of 289 patients with early invasive adenocarcinoma undergoing thoracoscopic lobotomy and a follow-up period of 3 months after surgery. Blood was collected the day before surgery for miRNA detection and patient information including operation duration, duration of continuous drainage of the chest, leukocyte count before and after operation, and postoperative pain scores were recorded. Using clinical and biochemical information for each patient, the risk factors for chronic postsurgical pain and related miRNA phenotypes were screened. We found that chronic postsurgical pain was associated with higher body mass index; greater preoperative history of chronic pain; longer postoperative drainage tube retention duration; higher numerical rating scale scores one, two, and three days after surgery; and changes in miRNA expression, namely lower expression of miRNA 146a-3p and higher expression of miRNA 550a-3p and miRNA 3613-3p in peripheral blood (p < 0.05). Of these factors, patient body mass index, preoperative history of chronic pain, average numerical rating scale score after operation, and preoperative peripheral blood miRNA 550a-3P expression were independent risk factors for the development of chronic postsurgical pain. Identification of individual risk markers may aid the development and selection of appropriate preventive and control measures.