# Sublingual human chorionic gonadotropin as an adjuvant to ovulation induction

## TL;DR

This study investigated whether sublingual human chorionic gonadotropin improves ovulation induction when combined with other medications, but found no significant overall benefit.

## Contribution

The study introduces sublingual HCG as a potential adjuvant in ovulation induction protocols.

## Key findings

- No statistically significant differences in ovulation induction were observed between the groups.
- A moderately positive correlation between sublingual HCG with CC and endometrial thickening was detected.
- The number of pre-ovulatory follicles did not show significant changes.

## Abstract

To evaluate the efficacy of sublingually administered human chorionic
gonadotropin (HCG) in combination with clomiphene citrate (CC) or letrozole
(LTZ) for ovulation induction.

In this prospective, double-blind, randomized study, the patients were
divided into two placebo groups and two intervention groups using CC, LTZ,
and HCG.

There were no statistically significant differences in ovulation induction
between the groups. We compared endometrial thickness at the beginning of
the cycle and during the pre-ovulatory period, and detected a moderately
positive correlation when CC was administered with HCG.

Sublingual HCG with CC caused a moderately positive correlation with
endometrial thickening when compared with that at the beginning of the cycle
and during the pre-ovulatory period. There was no significant change in the
number of pre-ovulatory follicles.